diff --git a/sqlx-postgres/src/advisory_lock.rs b/sqlx-postgres/src/advisory_lock.rs
index 84cad2bfdd..979aca06ce 100644
--- a/sqlx-postgres/src/advisory_lock.rs
+++ b/sqlx-postgres/src/advisory_lock.rs
@@ -3,6 +3,8 @@ use crate::Either;
 use crate::PgConnection;
 use hkdf::Hkdf;
 use sha2::Sha256;
+use sqlx_core::executor::Executor;
+use sqlx_core::sql_str::SqlSafeStr;
 use std::ops::{Deref, DerefMut};
 use std::sync::Arc;
 use std::sync::OnceLock;
@@ -199,27 +201,36 @@ impl PgAdvisoryLock {
     /// See [Postgres' documentation for the Advisory Lock Functions][advisory-funcs] for details.
     ///
     /// [advisory-funcs]: https://www.postgresql.org/docs/current/functions-admin.html#FUNCTIONS-ADVISORY-LOCKS
+    ///
+    /// # Cancel Safety
+    ///
+    /// This method is cancel safe. If the future is dropped before the query completes, a
+    /// `pg_advisory_unlock()` call is queued and run the next time the connection is used.
     pub async fn acquire<C: AsMut<PgConnection>>(
         &self,
         mut conn: C,
     ) -> Result<PgAdvisoryLockGuard<C>> {
+        let query = match &self.key {
+            PgAdvisoryLockKey::BigInt(_) => "SELECT pg_advisory_lock($1)",
+            PgAdvisoryLockKey::IntPair(_, _) => "SELECT pg_advisory_lock($1, $2)",
+        };
+
+        let stmt = conn.as_mut().prepare(query.into_sql_str()).await?;
+        let query = crate::query::query_statement(&stmt);
+
+        // We're wrapping the connection in a `PgAdvisoryLockGuard` early here on purpose. If this
+        // future is dropped, the lock will be released in the drop impl.
+        let mut guard = PgAdvisoryLockGuard::new(self.clone(), conn);
+        let conn = guard.conn.as_mut().unwrap();
+
         match &self.key {
-            PgAdvisoryLockKey::BigInt(key) => {
-                crate::query::query("SELECT pg_advisory_lock($1)")
-                    .bind(key)
-                    .execute(conn.as_mut())
-                    .await?;
-            }
-            PgAdvisoryLockKey::IntPair(key1, key2) => {
-                crate::query::query("SELECT pg_advisory_lock($1, $2)")
-                    .bind(key1)
-                    .bind(key2)
-                    .execute(conn.as_mut())
-                    .await?;
-            }
+            PgAdvisoryLockKey::BigInt(key) => query.bind(key),
+            PgAdvisoryLockKey::IntPair(key1, key2) => query.bind(key1).bind(key2),
         }
+        .execute(conn.as_mut())
+        .await?;
 
-        Ok(PgAdvisoryLockGuard::new(self.clone(), conn))
+        Ok(guard)
     }
 
     /// Acquires an exclusive lock using `pg_try_advisory_lock()`, returning immediately
@@ -242,6 +253,12 @@ impl PgAdvisoryLock {
     /// See [Postgres' documentation for the Advisory Lock Functions][advisory-funcs] for details.
     ///
     /// [advisory-funcs]: https://www.postgresql.org/docs/current/functions-admin.html#FUNCTIONS-ADVISORY-LOCKS
+    ///
+    /// # Cancel Safety
+    ///
+    /// This method is **not** cancel safe. If the future is dropped while the query is in-flight,
+    /// it is not possible to know whether the lock was acquired, so it cannot be safely released.
+    /// The lock may remain held until the connection is closed.
     pub async fn try_acquire<C: AsMut<PgConnection>>(
         &self,
         mut conn: C,