How is extremely high-coverage defined?

[bfurtwa]

On the page http://millstone.readthedocs.io/en/latest/user_guide/intro.html there is the following written:

"Note: Extremely high-coverage samples and short fragments with non-overlapping reads might cause difficulties. Try at your own risk. You might consider downsampling or cleaning the reads first"

I have paired-reads of a bacterial genome with coverage of 300. Is this already extremely high?

[glebkuznetsov]

Paired-reads with coverage 300 should be fine; in fact, that sounds ideal.

We were referring to cases where users had sequenced plasmids at 5000x coverage.